Phosphatidylinositol 3-Kinase Controls Antineutrophil Cytoplasmic Antibodies—Induced Respiratory Burst in Human Neutrophils
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چکیده
منابع مشابه
Inhibition of phosphatidylinositol 4-kinase results in a significant reduced respiratory burst in formyl-methionyl-leucyl-phenylalanine-stimulated human neutrophils.
The effects of phenylarsine oxide and a monoclonal antibody directed against type II phosphatidylinositol 4-kinase (PI4K) on the N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated respiratory burst and the PI4K activity in neutrophils were investigated. Fluorescence microscopic imaging showed that the antibody labeled with IANBD amide (N,N'-dimethyl-N-(iodoacetyl)-N'-(7-nitrobenz-2-oxa-1...
متن کاملANTINEUTROPHIL CYTOPLASMIC AUTOANTIBODI ES IN RHEUMATOID ARTHRITIS
Antineutrophil cytoplasmic autoantibodies (ANCA) were detected in patients with autoimmune and vascular diseases such as Wegener's granulomatosis, polyarteritis nodosa and systemic lupus erythematosus. Indirect immunofluorescence (IIF) technique was employed to detect these autoantibodies. By this method, two general patterns of ANCA were seen: a cytoplasmic (cANCA) and a perinuclear form ...
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Myeloperoxidase (MPO), a heme enzyme present in the primary granules of polymorphonuclear leukocytes (PMNs), has been demonstrated to participate in the oxygen-dependent microbicidal activity of these cells. Evidence for the importance of MPO in this role comes in part from studies of normal PMNs treated with the heme enzyme inhibitor, sodium azide. MPO has also been suggested to regulate the r...
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Recent evidence has suggested that a particulate O(2) (-)-forming system is responsible for the respiratory burst in activated neutrophils. The respiratory burst is normally a transient event, lasting only 30-60 min. To investigate the mechanism by which the burst is terminated, we examined the O(2) (-)-forming activity of neutrophil particles as a function of time in the presence and absence o...
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Introduction: Although exercise his effects on human immune system, but its causes is not significantly cleared yet. This study is aimed to investigate the effect of exercise with moderate and high intensity, on changes of respiratory burst activities and neutrophil counts in college judoists. Methods: 10 male college judoists participated in this quazi-experimental study. Subjects run o...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2002
ISSN: 1046-6673,1533-3450
DOI: 10.1097/01.asn.0000019411.36000.06